Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection
Substantial clinical evidence supports the notion that ciliary function in the airways is important in COVID-19 pathogenesis.Although ciliary damage has been observed in both in vitro and in vivo models, the extent or nature of impairment of mucociliary transport (MCT) in in vivo models remains unknown.We hypothesize that SARS-CoV-2 infection resul